Greyhound is a national bus operator with service throughout the lower 48-states. In the Bay Area and Los Angeles regions, Greyhound can be a suitable alternative for trips that involve multiple transit operators. However, given the long distance nature of the routes, service is generally less frequent and more expensive.
In some regions, transit agencies are not interconnected and Greyhound (and Amtrak to some extent) is the only mode connecting these cities. In rural areas, some transit agencies provide connecting bus service from various communities to Greyhound bus stops located in larger cities.
Some of the Greyhound terminals are located at or adjacent to major transit centers. Others are located a few blocks away.